Antonino was established in 1904 after parishioners of the St. Francis Church in Munjor requested a new parish due to the distance from their homes. Its residents wanted to name it St. Anthony, but, when they went to establish a post office, the name was denied because of a town in Harper County named Anthony. Antonino was chosen after a village that some of the pioneers had lived in while in Brazil, and a post office was established in May, 1905.
Our Lady Help of Christians Catholic Church, a frame building, was built in 1904-1905. Antonino never grew much, but a school was built in 1939 and maintaining its parish congregation, a new brick church was built in 1951-52. Though Antonino is still called home to a few people, its post office closed its doors forever in February, 1884. The church still serves parishioners today.
Antonino is located about eight miles southwest of Hays.